Rekombinanter FOLR1 Antikörper

Produktnummer ABIN7865464

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch FOLR1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Meerschweinchen und Hamster.

Kurzübersicht für Rekombinanter FOLR1 Antikörper (ABIN7865464)

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Hamster

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser FOLR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: FOLR1-12910R

Produktdetails anti-FOLR1 Antikörper

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant Folate Receptor Alpha (FRalpha) / FOLR1 Antibody

Spezifität: Folate receptor alpha (FR±) is a membrane-bound protein that facilitates high-affinity folate transport, essential for cell metabolism, DNA synthesis, and repair, particularly in rapidly dividing cancer cells with increased folate demands. This receptor, encoded by the FOLR1 gene, employs a potocytosis mechanism that leads to both membranous and cytoplasmic localization and is selectively overexpressed in certain epithelial malignancies while remaining highly restricted in normal tissues. FR± expression correlates with tumor stage and grade, suggesting a role in tumor progression by enhancing folate uptake or generating regulatory signals. Its regulation is influenced by extracellular folate levels, homocysteine accumulation, hormones, transcription factors, and genetic mutations. Members of the folate receptor family share highly conserved sequences in the open reading frames but differ in amino acids in the 5' untranslated regions and as a consequence can differ in function and tissue expression. Given the selective overexpression of FR± in tumors and its association with aggressive cancer phenotypes, FR± is a valuable marker for studying tumor biology and progression, particularly in epithelial cancers.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant fragment of human FOLR1 protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Andere Bezeichnung: Folate Receptor Alpha

Hintergrund:

DOM, PCWH, SOX10, SRY (sex determining region Y) box 10, SRY box containing gene 10, SRY related HMG box gene 10, Waardenburg syndrome type 2E(WS2E), WS4, Waardenburg syndrome type 4C (WS4C)

Human kidney, thymus, placenta or lung. Human Brain, Mouse Brain, Rat Brain, Hamster Brain or Guinea pig Brain

Molekulargewicht: 29kDa

Gen-ID: 2348

UniProt: P15328

Pathways: Dicarboxylic Acid Transport