Rekombinanter FOLR1 Antikörper

Produktnummer ABIN7857790

Der Maus Monoklonal anti-FOLR1 Antikörper (Klon rFOLR1-13324) (ABIN7857790) detektiert spezifisch FOLR1 in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter FOLR1 Antikörper (ABIN7857790)

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOLR1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: RFOLR1-13324

Produktdetails anti-FOLR1 Antikörper

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant Folate Receptor Alpha (FRalpha) / FOLR1 Antibody

Spezifität: Folate receptor alpha (FR±) is a membrane-bound protein that facilitates high-affinity folate transport, essential for cell metabolism, DNA synthesis, and repair, particularly in rapidly dividing cancer cells with increased folate demands. This receptor, encoded by the FOLR1 gene, employs a potocytosis mechanism that leads to both membranous and cytoplasmic localization and is selectively overexpressed in certain epithelial malignancies while remaining highly restricted in normal tissues. FR± expression correlates with tumor stage and grade, suggesting a role in tumor progression by enhancing folate uptake or generating regulatory signals. Its regulation is influenced by extracellular folate levels, homocysteine accumulation, hormones, transcription factors, and genetic mutations. Members of the folate receptor family share highly conserved sequences in the open reading frames but differ in amino acids in the 5' untranslated regions and as a consequence can differ in function and tissue expression. Given the selective overexpression of FR± in tumors and its association with aggressive cancer phenotypes, FR± is a valuable marker for studying tumor biology and progression, particularly in epithelial cancers.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant human FOLR1 protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Andere Bezeichnung: Folate Receptor Alpha

Hintergrund:

DOM, PCWH, SOX10, SRY (sex determining region Y) box 10, SRY box containing gene 10, SRY related HMG box gene 10, Waardenburg syndrome type 2E(WS2E), WS4, Waardenburg syndrome type 4C (WS4C)

Human kidney, thymus, placenta or lung.

Molekulargewicht: 29kDa

Gen-ID: 2348

UniProt: P15328

Pathways: Dicarboxylic Acid Transport