Rekombinanter Renal Cell Carcinoma (Gp200) (AA 80-100), (N-Term) Antikörper

Produktnummer ABIN7865169

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Renal Cell Carcinoma (Gp200) in IHC und WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Meerschweinchen.

Kurzübersicht für Rekombinanter Renal Cell Carcinoma (Gp200) (AA 80-100), (N-Term) Antikörper (ABIN7865169)

Target: Renal Cell Carcinoma (Gp200)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte, Meerschweinchen

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Klon: CA9-9621R

Produktdetails

Bindungsspezifität: AA 80-100, N-Term

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant Renal Cell Carcinoma (Carbonic Anhydrase IX) Antibody

Spezifität: Recognizes a glycoprotein of ~200 kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93 % of primary and 84 % of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Extracellular N-terminal proteoglycan-like region. Epitope is between aa80-100.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Antigendetails

Target: Renal Cell Carcinoma (Gp200)

Andere Bezeichnung: Renal Cell Carcinoma

Hintergrund:

CA-IX, CA9, CAIX, Carbonate dehydratase IX, Carbonic anhydrase 9, Carbonic anhydrase IX, Carbonic dehydratase, G250, Membrane antigen MN, P54/58N, pMW1, RCC-associated antigen G250, Renal cell carcinoma-associated antigen G250

HeLa cells. Normal kidney or Human Stomach, Rat Stomach or Guinea pig Stomach (WB) renal cell carcinoma (IHC).

Molekulargewicht: 55kDa

Gen-ID: 768, 63287

UniProt: Q16790