Rekombinanter ERG Antikörper (AA 1-300)

Produktnummer ABIN7857613

Der Kaninchen Monoklonal anti-ERG Antikörper (Klon ERG-9604R) (ABIN7857613) detektiert spezifisch ERG in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter ERG Antikörper (AA 1-300) (ABIN7857613)

Target: ERG (ERG, ETS transcription factor (ERG))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ERG Antikörper ist unkonjugiert

Applikation: ELISA

Klon: ERG-9604R

Produktdetails anti-ERG Antikörper

Bindungsspezifität: AA 1-300

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant ERG / ETS Transcription Factor (Prostate Cancer Marker) Antibody

Spezifität: ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumor, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumor, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant fragment (around aa1-300) of human ERG protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu ERG

Target: ERG (ERG, ETS transcription factor (ERG))

Andere Bezeichnung: ERG

Hintergrund:

ERG, ERG/EWS fusion gene, ERG/FUS fusion gene, ERG/TMPSSR2 fusion gene, ERG1, ETS-related, KCNH2, Oncogene ERG, p55, TMPRSS2/ERG fusion

Human tonsil, Ewing sarcoma or prostate adenocarcinoma.

Molekulargewicht: 55kDa

Gen-ID: 2078, 473819

UniProt: P11308