TRIM63 Antikörper (AA 251-353)

Produktnummer ABIN741750

Dieses Anti-TRIM63-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TRIM63 in WB, ELISA, FACS, IF (cc), IF (p), IHC (p) und IHC (fro). Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für TRIM63 Antikörper (AA 251-353) (ABIN741750)

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM63 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-TRIM63 Antikörper

Bindungsspezifität: AA 251-353

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MuRF1/Trim63

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TRIM63 Antikörper (ABIN741750)

Lu, Wang, Xie, Zhang, Sun: "Tumor necrosis factor-like weak inducer of apoptosis regulates quadriceps muscle atrophy and fiber-type alteration in a rat model of chronic obstructive pulmonary disease." in: Tobacco induced diseases, Vol. 15, pp. 43, (2017) (PubMed).

Lin, Hanson, Betik, Brennan-Speranza, Hayes, Levinger: "Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 11, pp. 1967-1978, (2016) (PubMed).

Details zu TRIM63

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Andere Bezeichnung: MuRF1/Trim63

Hintergrund:

Synonyms: MuRF 1, MuRF-1, Muscle-specic RING finger protein 1, Muscle-specic RING finger protein 1, E3 ubiquitin-protein ligase TRIM63, FLJ32380, IRF, MURF1, MURF 1, MURF2, RNF28, SMRZ, Iris ring finger protein, Muscle specic ring finger protein 2, Ring finger protein 28, RNF28, SMRZ, Striated muscle RING zinc finger protein, TRIM 63, TRIM63, Tripartite mot containing 63, Tripartite mot containing protein 63, Ubiquitin ligase TRIM63.

Background: This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle. [provided by RefSeq].

Gen-ID: 84676