SREBF2 Antikörper (Biotin)

Produktnummer ABIN741707

Der Kaninchen Polyklonal anti-SREBF2 Antikörper wird verwendet zum Nachweis von SREBF2 in Proben von Human. Er wurde validiert für IHC (p) und IHC (fro).

Kurzübersicht für SREBF2 Antikörper (Biotin) (ABIN741707)

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SREBF2 Antikörper ist konjugiert mit Biotin

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-SREBF2 Antikörper (Biotin)

Verwendungszweck: SREBP2 Polyclonal Antibody, Biotin Conjugated

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SREBP-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P(1:200-400), IHC-F(1:100-500)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SREBF2

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Andere Bezeichnung: SREBP-2

Hintergrund:

Synonyms: Sterol Regulatory Element Binding Protein-2, MGC124823, Srebf2_retired, SREBP-2, SREBP2, SRBP2_HUMAN, Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2.

Background: Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. ab30682 detects both precursor and active forms of SREBP2 in tissues and cells such as liver, brown fat, testis, HepG2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to glycosylation of the protein.

Molekulargewicht: 126kDa

Gen-ID: 6721

Pathways: Regulation of Lipid Metabolism by PPARalpha