CD163 Antikörper (PE-Cy5)

Produktnummer ABIN741582

Dieses Anti-CD163-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD163 in WB und FACS. Geeignet für Human, Maus, Ratte, Schwein, Hund und Rind (Kuh).

Kurzübersicht für CD163 Antikörper (PE-Cy5) (ABIN741582)

Target: CD163

Reaktivität: Human, Maus, Ratte, Schwein, Hund, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD163 Antikörper ist konjugiert mit PE-Cy5

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-CD163 Antikörper (PE-Cy5)

Kreuzreaktivität: Hund, Human, Maus, Schwein, Ratte

Homologie: Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD163/M130

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:100-500)
IHC-P(1:100-500)
IF(IHC-P)(1:100-500)
IF(ICC)(1:100-500)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CD163

Target: CD163

Andere Bezeichnung: CD163/M130

Hintergrund:

Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Molekulargewicht: 130kDa

Gen-ID: 9332

UniProt: Q86VB7