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CD163 Antikörper (AA 1001-1121) (FITC)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CD163 in WB, FACS, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Schwein und Hund und wurde in 3+ Publikationen erwähnt.
Produktnummer ABIN741577

Kurzübersicht für CD163 Antikörper (AA 1001-1121) (FITC) (ABIN741577)

Target

Alle CD163 Antikörper anzeigen
CD163

Reaktivität

  • 181
  • 52
  • 46
  • 30
  • 18
  • 5
  • 3
  • 2
  • 1
  • 1
Human, Maus, Ratte, Schwein, Hund

Wirt

  • 123
  • 107
  • 2
  • 1
Kaninchen

Klonalität

  • 127
  • 105
  • 1
Polyklonal

Konjugat

  • 93
  • 19
  • 19
  • 9
  • 6
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD163 Antikörper ist konjugiert mit FITC

Applikation

  • 148
  • 100
  • 86
  • 58
  • 49
  • 36
  • 30
  • 26
  • 26
  • 25
  • 21
  • 21
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 36
    • 16
    • 15
    • 15
    • 11
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1001-1121

    Kreuzreaktivität

    Hund, Human, Maus, Schwein, Ratte

    Homologie

    Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human CD163/M130

    Isotyp

    IgG
  • Applikationshinweise

    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Kobori, Hamasaki, Kitaura, Yamazaki, Nishinaka, Niwa, Nakao, Wake, Mori, Yoshino, Nishibori, Takahashi: "Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis." in: Frontiers in immunology, Vol. 9, pp. 334, (2019) (PubMed).

    Oh, Riek, Zhang, Williams, Darwech, Bernal-Mizrachi: "Deletion of JNK2 prevents vitamin-D-deficiency-induced hypertension and atherosclerosis in mice." in: The Journal of steroid biochemistry and molecular biology, Vol. 177, pp. 179-186, (2017) (PubMed).

    Weng, Sprague, Oh, Riek, Chin, Garcia, Bernal-Mizrachi: "Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice." in: PLoS ONE, Vol. 8, Issue 1, pp. e54625, (2013) (PubMed).

  • Target

    CD163

    Andere Bezeichnung

    Cd163/M130

    Hintergrund

    Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

    Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

    Gen-ID

    9332

    UniProt

    Q86VB7
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