CD163 Antikörper (AA 1001-1121) (Biotin)

Produktnummer ABIN741572

Der Kaninchen Polyklonal Anti-CD163-Antikörper wurde für WB, ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, CD163 in Proben von Human, Maus, Ratte, Schwein und Hund zu detektieren.

Kurzübersicht für CD163 Antikörper (AA 1001-1121) (Biotin) (ABIN741572)

Target: CD163

Reaktivität: Human, Maus, Ratte, Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD163 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CD163 Antikörper (Biotin)

Bindungsspezifität: AA 1001-1121

Kreuzreaktivität: Hund, Human, Maus, Schwein, Ratte

Homologie: Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD163/M130

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CD163

Target: CD163

Andere Bezeichnung: Cd163/M130

Hintergrund:

Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Gen-ID: 9332

UniProt: Q86VB7