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CD163 Antikörper (AA 1001-1121)

Dieses Anti-CD163-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD163 in WB, FACS, ELISA, IHC (p), ICC, IHC (fro), IF (cc) und IF (p). Geeignet für Human, Maus, Ratte, Schwein und Hund. Dieses Primary Antibody wurde in 27+ Publikationen zitiert.
Produktnummer ABIN741570

Kurzübersicht für CD163 Antikörper (AA 1001-1121) (ABIN741570)

Target

Alle CD163 Antikörper anzeigen
CD163

Reaktivität

  • 151
  • 52
  • 46
  • 30
  • 18
  • 5
  • 3
  • 2
  • 1
  • 1
Human, Maus, Ratte, Schwein, Hund

Wirt

  • 123
  • 77
  • 2
  • 1
Kaninchen

Klonalität

  • 105
  • 97
  • 1
Polyklonal

Konjugat

  • 86
  • 20
  • 16
  • 9
  • 6
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD163 Antikörper ist unkonjugiert

Applikation

  • 138
  • 86
  • 70
  • 57
  • 49
  • 35
  • 26
  • 25
  • 25
  • 21
  • 20
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 16
    • 15
    • 15
    • 11
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1001-1121

    Kreuzreaktivität

    Hund, Human, Maus, Schwein, Ratte

    Homologie

    Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human CD163/M130

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Riuzzi, Beccafico, Sagheddu, Chiappalupi, Giambanco, Bereshchenko, Riccardi, Sorci, Donato: "Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy." in: Scientific reports, Vol. 7, Issue 1, pp. 12537, (2019) (PubMed).

    Kobori, Hamasaki, Kitaura, Yamazaki, Nishinaka, Niwa, Nakao, Wake, Mori, Yoshino, Nishibori, Takahashi: "Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis." in: Frontiers in immunology, Vol. 9, pp. 334, (2019) (PubMed).

    Yin, Chang, Xu: "Expressions Profiles of the Proteins Associated with Carbohydrate Metabolism in Rat Liver Regeneration." in: BioMed research international, Vol. 2017, pp. 8428926, (2018) (PubMed).

    Chen, Zhang, Wang, Chen, Yan, Zhang, Zhang: "Peptide-modified chitosan hydrogels promote skin wound healing by enhancing wound angiogenesis and inhibiting inflammation." in: American journal of translational research, Vol. 9, Issue 5, pp. 2352-2362, (2017) (PubMed).

    Bobi, Solanes, Fernández-Jiménez, Galán-Arriola, Dantas, Fernández-Friera, Gálvez-Montón, Rigol-Monzó, Agüero, Ramírez, Roqué, Bayés-Genís, Sánchez-González, García-Álvarez, Sabaté, Roura, Ibáñez et al.: "Intracoronary Administration of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial ..." in: Journal of the American Heart Association, Vol. 6, Issue 5, (2017) (PubMed).

    Gerzanich, Makar, Guda, Kwon, Stokum, Woo, Ivanova, Ivanov, Mehta, Morris, Bryan, Bever, Simard: "Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 177, (2017) (PubMed).

    Lee, Liao, Wang, Yang, Luo, Varki, Qiu, Ren, Fu, Feng: "Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions." in: Cell reports, Vol. 21, Issue 7, pp. 1870-1882, (2017) (PubMed).

    Dinulovic, Furrer, Di Fulvio, Ferry, Beer, Handschin: "PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle." in: Skeletal muscle, Vol. 6, pp. 38, (2017) (PubMed).

    Tauchi, Tanaka, Kumamoto, Tokumoto, Sakimura, Sakurai, Kimura, Toyokawa, Amano, Kubo, Muguruma, Yashiro, Maeda, Ohira, Hirakawa: "Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer." in: Cancer science, Vol. 107, Issue 8, pp. 1101-9, (2017) (PubMed).

    Jacobsen, Mentzel, Olesen, Huby, Jørgensen, Barrès, Fredholm, Simar: "Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity." in: Journal of diabetes research, Vol. 2016, pp. 8539057, (2016) (PubMed).

    Kugo, Zaima, Tanaka, Mouri, Yanagimoto, Hayamizu, Hashimoto, Sasaki, Sano, Yata, Urano, Setou, Unno, Moriyama: "Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm." in: Scientific reports, Vol. 6, pp. 31268, (2016) (PubMed).

    Drel, Tan, Barnes, Gorin, Lee, Wagner: "Centrality of bone marrow in the severity of gadolinium-based contrast-induced systemic fibrosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 9, pp. 3026-38, (2016) (PubMed).

    Das, Singh, Majid, Sherman, Mukhopadhyay, Wright, Martin, Dunn, Baker: "Syndesome Therapeutics for Enhancing Diabetic Wound Healing." in: Advanced healthcare materials, Vol. 5, Issue 17, pp. 2248-60, (2016) (PubMed).

    Chen, Shi, Zhang, Chen, Wang, Zhang, Tian, Yan, Li, Zhong, Xing, Zhang, Zhang: "Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing." in: Scientific reports, Vol. 5, pp. 18104, (2016) (PubMed).

    Fernandez-Bustamante, Agazio, Wilson, Elkins, Domaleski, He, Baer, Moss, Wischmeyer, Repine et al.: "Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in ..." in: PLoS ONE, Vol. 10, Issue 7, pp. e0130764, (2016) (PubMed).

    Tepeköylü, Lobenwein, Blunder, Kozaryn, Dietl, Ritschl, Pechriggl, Blumer, Bitsche, Schistek, Kotsch, Fritsch, Grimm, Holfeld: "Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice†." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 47, Issue 3, pp. e80-90, (2015) (PubMed).

    Ge, Li, Jiang, You, Liu, Zhong, Huang, Xing: "Integration of nondegradable polystyrene and degradable gelatin in a core-sheath nanofibrous patch for pelvic reconstruction." in: International journal of nanomedicine, Vol. 10, pp. 3193-201, (2015) (PubMed).

    Franken, Klein, Spasova, Elsukova, Wiedwald, Welz, Knolle, Farle, Limmer, Kurts: "Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates." in: Scientific reports, Vol. 5, pp. 12940, (2015) (PubMed).

  • Target

    CD163

    Andere Bezeichnung

    Cd163/M130

    Hintergrund

    Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

    Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

    Gen-ID

    9332

    UniProt

    Q86VB7
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