AVEN Antikörper (AA 301-362)

Produktnummer ABIN740280

Dieser Anti-AVEN Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von AVEN in WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro). Geeignet für Human.

Kurzübersicht für AVEN Antikörper (AA 301-362) (ABIN740280)

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AVEN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-AVEN Antikörper

Bindungsspezifität: AA 301-362

Homologie: Human,Mouse,Rat,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AVEN

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Andere Bezeichnung: AVEN

Hintergrund:

Synonyms: 1700013A01Rik, 1700056A21Rik, mAven L, mAven S, MGC124011, Apoptosis caspase activation inhibitor, Cell death regulator Aven, OTTMUSP00000016129, PDCD12, Programmed cell death 12, RP23-52C15.2, AVEN_HUMAN

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients.

Gen-ID: 57099