FOXP3 Antikörper

Produktnummer ABIN7828864

Dieser Ratte Monoklonal Antikörper detektiert spezifisch FOXP3 in FACS. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für FOXP3 Antikörper (ABIN7828864)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: FJK-16s

Produktdetails anti-FOXP3 Antikörper

Verwendungszweck: Purified Anti-Mouse Foxp3 Antibody[FJK-16s]

Aufreinigung: >98%, Protein A/G purified

Reinheit: >98 %

Immunogen: Recombinant Mouse FOXP3 protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: FCM 2 μg/mL(0.5x106-1x106 cells)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: ≥ 1 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.05 % non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: FOXP3

Hintergrund: Forkhead box protein P,FOXP,Forkhead box protein P3,IPEX,JM2,Foxp3,AIID,DIETER,Forkhead box P3,FOXP3delta7,Immune dysregulation polyendocrinopathy enteropathy X linked,Immunodeficiency polyendocrinopathy enteropathy X linked,MGC141961,MGC141963,OTTHUMP00000025832,OTTHUMP00000025833,OTTHUMP00000226737,PIDX,Scurfin,XPID,FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation