Rekombinanter TTR Antikörper

Produktnummer ABIN7828640

Der Kaninchen Monoklonal anti-TTR Antikörper wird verwendet zum Nachweis von TTR in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter TTR Antikörper (ABIN7828640)

Target: TTR (Transthyretin (TTR))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TTR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A768

Produktdetails anti-TTR Antikörper

Verwendungszweck: Recombinant Prealbumin/Transthyretin Monoclonal Antibody

Aufreinigung: Protein A purified

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:1000,IHC 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu TTR

Target: TTR (Transthyretin (TTR))

Andere Bezeichnung: Prealbumin/Transthyretin

Hintergrund: HEL,HsT,TTR,CTS,CTS1,HEL111,HsT2651,PALB,TBPA,ATTR,Prealbumin,Transthyretin,Amyloid polyneuropathy,Amyloidosis I,Carpal tunnel syndrome 1,Dysprealbuminemic euthyroidal hyperthyroxinemia,Dystransthyretinemic hyperthyroxinemia,Epididymis luminal protein 111,Prealbumin amyloidosis type I,Prealbumin Thyroxine-binding,Senile systemic amyloidosis,Thyroxine binding prealbumin,Transthyretin,TTR,TTHY,TTR protein,Transthyretin (TTR) is a highly conserved homotetremric protein that is synthesized in the liver and choroid plexus of the brain. TTR wasoriginally discovered as a protein found in human plasma and cerebrospinal fluid (CSF). TTR transports thyroid hormones (TH) and retinol bybinding to retinol-binding protein. Although TTR is synthesized in the liver and choroid plexus, TTR is detected in blood plasma andcerebrospinal fluid migrating as monomers, dimers, and tetramers. Beyond its function as a carrier protein of TH and retinol in plasma andCSF, several additional TTR functions have been described, including proteolytic cleavage of specific substrates like apolipoprotein,neuropeptide Y (NPY), and APP. These neuronal substrates suggest a functional role for TTR in the central nervous system. Consistent witha CNS function, TTR null mice exhibit memory impairments and altered sensorimotor behavior). TTR may also be linked to neurodegenerativedisease: TTR levels in Alzheimer's disease (AD) patients are negatively correlated with disease progression, and a protective role for TTR, atleast in AD mouse models, has been described. TTR itself may play a more direct role in disease as gain-of-function mutations in TTR causethe protein to misfold and aggregate into amyloid fibrils, contributing to autosomal dominant hereditary amyloidosis in diseases such as familialamyloid polyneuropathy, familial amyloid cardiomyopathy, and familial leptomeningeal amyloidosis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 16 kDa

Observed MW: 35 kDa The actual band is not consistent with the expectation.

UniProt: P02766

Pathways: Hormone Transport