Rekombinanter TBL1XR1 Antikörper

Produktnummer ABIN7828633

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch TBL1XR1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter TBL1XR1 Antikörper (ABIN7828633)

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TBL1XR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A640

Produktdetails anti-TBL1XR1 Antikörper

Verwendungszweck: Recombinant TBLR1/TBL1XR1 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human TBLR1/TBL1XR1 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:2000-1:5000,IHC 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu TBL1XR1

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Andere Bezeichnung: TBLR1/TBL1XR1

Hintergrund: MRD,IRA,TBLR,TBL1XR,TBL1XR1,C21,DC42,IRA1,MRD41,TBLR1,TBL1-related protein 1 (TBLR1/TBL1XR1) and Transducing β-like protein 1 (TBL1X/TBL1) were originally identified as subunits of the co-repressor silencing mediator for retinoic and thyroid hormone receptor (SMRT) and nuclear receptor co-repressor (NCoR) complexes. These two factors are required for the exchange of co-repressor complexes for co-activators by acting as adaptors to recruit the ubiquitin/proteasome machinery that degrades the co-repressor proteins during ligand mediated activation of transcription. Co-factor exchange driven by TBLR1/TBL1XR1 and TBL1X/TBL1 appears to be the mechanism by which c-Jun and NF-κB mediated transcription is activated and is therefore likely to be the mechanism employed by other signal-dependent transcription factors as well. In addition, both TBLR1/TBL1XR1 and TBL1X/TBL1 have essential roles in regulating the Wnt-signaling pathway by recruiting β-catenin to Wnt target genes to activate transcription. Depletion of TBLR1/TBL1XR1 significantly inhibited Wnt-beta-catenin- induced gene expression and oncogenic growth in vitro and in vivo. Research studies have shown that upregulation of TBLR1/TBL1XR1 is observed in a variety of solid tumors, and is correlated with advanced tumor stage, metastasis and poor prognosis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 56 kDa

Observed MW: 60 kDa The actual band is not consistent with the expectation.

UniProt: Q9BZK7

Pathways: Regulation of Lipid Metabolism by PPARalpha