Rekombinanter RAG2 Antikörper

Produktnummer ABIN7828521

Der Kaninchen Monoklonal anti-RAG2 Antikörper (Klon A350) (ABIN7828521) detektiert spezifisch RAG2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Rekombinanter RAG2 Antikörper (ABIN7828521)

Target: RAG2 (Recombination Activating Gene 2 (RAG2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser RAG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: A350

Produktdetails anti-RAG2 Antikörper

Verwendungszweck: Recombinant RAG2 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human RAG2 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu RAG2

Target: RAG2 (Recombination Activating Gene 2 (RAG2))

Andere Bezeichnung: RAG2

Hintergrund: RAG,RAG2,RAG-2,recombination activating 2,recombination activating gene 2,Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 62 kDa

Observed MW: 62 kDa

UniProt: P55895

Pathways: Chromatin Binding, Production of Molecular Mediator of Immune Response