Rekombinanter MPHOSPH8 Antikörper

Produktnummer ABIN7828368

Der Kaninchen Monoklonal anti-MPHOSPH8 Antikörper (Klon A305) (ABIN7828368) detektiert spezifisch MPHOSPH8 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für Rekombinanter MPHOSPH8 Antikörper (ABIN7828368)

Target: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MPHOSPH8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: A305

Produktdetails anti-MPHOSPH8 Antikörper

Verwendungszweck: Recombinant MPP8 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human MPP8 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu MPHOSPH8

Target: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Andere Bezeichnung: MPP8

Hintergrund: MPP,Mphosph,MPP8,MPHOSPH8,Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 110 kDa

Observed MW: 125 kDa The actual band is not consistent with the expectation.

UniProt: Q99549