Rekombinanter Histone H2B Antikörper

Produktnummer ABIN7828263

Der Kaninchen Monoklonal anti-Histone H2B Antikörper (Klon A831) (ABIN7828263) detektiert spezifisch Histone H2B in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter Histone H2B Antikörper (ABIN7828263)

Target: Histone H2B

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Histone H2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A831

Produktdetails anti-Histone H2B Antikörper

Verwendungszweck: Recombinant Histone H2B (Ubiquityl Lys120) Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Ubiquitinated human histone H2B (Lys120) peptide

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000,IHC 1:200-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu Histone H2B

Target: Histone H2B

Hintergrund: HIST1H2BG,H2B.1A,H2B/a,H2BFA,H2BFL,HIST1H2BC,H2BFH,HIST1H2BE,H2BFG,HIST1H2BF,H2BFK,HIST1H2BI,H2BC4,H2BC6,H2BC7,H2BC8,H2BC10,Ubiquitin (Ub) is a highly conserved 76-amino acid protein that plays a critical role in regulating a wide range of cellular processes. Through a three-step process involving Ub-activating (E1), Ub-conjugating (E2), and Ub-ligating (E3) enzymes, ubiquitin covalently attaches to target proteins and marks them for proteasomal degradation, alters protein-protein interactions, modulates membrane protein trafficking, and controls the activity of many signal transduction pathways. Mono-ubiquitination of Histone H2B at Lys120 (H2BK120ub) serves signaling purposes and is reversible by ubiquitin-specific proteases (USPs). The enzymes responsible for H2BK120ub are Rad6 E2 proteins (HR6A and HR6B in human) and Bre1 E3 ligase (RNF20 and RNF40 in human). This modification triggers a ""trans-histone"" modification cascade, resulting in trimethylation of Lys4 and Lys79 in histone H3, which promotes gene activity. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 23 kDa

Observed MW: 23 kDa

UniProt: P62807