Rekombinanter CPS1 Antikörper

Produktnummer ABIN7828062

Der Kaninchen Monoklonal anti-CPS1 Antikörper (Klon A622) (ABIN7828062) detektiert spezifisch CPS1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für Rekombinanter CPS1 Antikörper (ABIN7828062)

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CPS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A622

Produktdetails anti-CPS1 Antikörper

Verwendungszweck: Recombinant CPS1 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human CPS1 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:5000,IHC 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu CPS1

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Andere Bezeichnung: CPS1

Hintergrund: CPS,carbamoyl-phosphate synthase,CPSASE,CPS1,CPSASE1,PHN,carbamoyl-phosphate synthase 1,carbamoyl-phosphate synthase 1,CPSASE1,PHN,Carbamoyl phosphate synthase,Carbamoyl phosphate synthase [ammonia],Carbamoyl phosphate synthase [ammonia] mitochondrial,Carbamoyl phosphate synthetase 1,Carbamoyl phosphate synthetase 1 mitochondrial,Carbamoyl phosphate synthetase I,Carbamoylphosphate synthase,Carbamoyl-phosphate synthase [ammonia],Carbamoylphosphate synthetase 1,Carbamoylphosphate synthetase I,Carbamoyl-phosphate synthetase I,CPS 1,CPSase 1,CPSase I,CPSM,mitochondrial,MS738,Carbamoyl phosphate synthetase 1 (CPS1), a rate-limiting enzyme in the urea cycle, catalyzes the conversion of ammonia and bicarbonate to carbamoyl phosphate in mitochondria. Non-small cell lung carcinoma (NSCLC) cells with oncogenicKRASand loss of the tumor suppressor LKB1 express CPS1 and depend on this enzyme for growth. CPS1 maintains pyrimidine/purine balance in these cancer cells. Silencing CPS1 reduces the pyrimidine to purine ratio and stalls DNA synthesis, leading to DNA damage and cancer cell death. In addition, the tumor suppressor p53 represses the expression of urea cycle enzymes CPS1, OTC, and ARG1 and, therefore, causes the accumulation of ammonia, suppressing cancer growth. Furthermore, research studies suggest that hypermethylation-mediated downregulation ofCPS1expression may contribute to the progression of normal hepatocytes to hepatocellular carcinoma (HCC). Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 165 kDa

Observed MW: 165 kDa

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process