AXIN2 Antikörper (AA 86-812)

Produktnummer ABIN7825283

Dieser Anti-AXIN2-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von AXIN2 in IHC. Geeignet für Zebrafisch (Danio rerio).

Kurzübersicht für AXIN2 Antikörper (AA 86-812) (ABIN7825283)

Target: AXIN2 (Axin 2 (AXIN2))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AXIN2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-AXIN2 Antikörper

Bindungsspezifität: AA 86-812

Verwendungszweck: Anti-Zebrafish AXIN2 Antibody

Produktmerkmale: Anti-Zebrafish AXIN2 Antibody catalog #AZP57095. Tested in IHC applications. This antibody reacts with Zebrafish.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived zebrafish AXIN2 recombinant protein (Position: H86-D812)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry, 2-5 μg/mL, Zebrafish

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu AXIN2

Target: AXIN2 (Axin 2 (AXIN2))

Andere Bezeichnung: AXIN2

Hintergrund: Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

UniProt: P57095

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling