N-Cadherin Antikörper (AA 701-800)

Produktnummer ABIN738726

Dieses Anti-N-Cadherin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von N-Cadherin in WB, ELISA, IHC (p), IF (cc), IF (p) und IHC (fro). Geeignet für Human, Maus, Ratte, Rind (Kuh) und Zebrafisch (Danio rerio). Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für N-Cadherin Antikörper (AA 701-800) (ABIN738726)

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser N-Cadherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-N-Cadherin Antikörper

Bindungsspezifität: AA 701-800

Kreuzreaktivität: Rind (Kuh), Human, Maus, Ratte, Zebrafisch (Danio rerio)

Homologie: Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human N-cadherin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-N-Cadherin Antikörper (ABIN738726)

Yang, Li, Qi, Li, Zhou, Qing, Zhang, Gao: "lncRNA H19 is involved in TGF-β1-induced epithelial to mesenchymal transition in bovine epithelial cells through PI3K/AKT Signaling Pathway." in: PeerJ, Vol. 5, pp. e3950, (2017) (PubMed).

Park, Kim, Lee: "Interaction-tailored cell aggregates in alginate hydrogels for enhanced chondrogenic differentiation." in: Journal of biomedical materials research. Part A, Vol. 105, Issue 1, pp. 42-50, (2016) (PubMed).

Liu, Cui, Ao, Zhou, Zhou, Yuan, Xiang, Liu, Cao et al.: "Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ..." in: Toxicology and applied pharmacology, Vol. 251, Issue 1, pp. 70-8, (2011) (PubMed).

Details zu N-Cadherin

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Andere Bezeichnung: N-cadherin

Hintergrund:

Synonyms: CDHN, NCAD, CD325, CDw325, Cadherin-2, Neural cadherin, N-cadherin, CDH2, CADH2_HUMAN

Background: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Gen-ID: 1000

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane