Rekombinanter PD-1 & VEGF-A Antikörper

Produktnummer ABIN7795547

Dieser Maus Bispecific Antikörper detektiert spezifisch PD-1 & VEGF-A in ELISA, FACS, ICC, IHC, in vivo und WB. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für Rekombinanter PD-1 & VEGF-A Antikörper (ABIN7795547)

Target: PD-1 & VEGF-A

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Maus

Klonalität: Bispecific

Konjugat: Unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), In vivo Studies (in vivo), Western Blotting (WB)

Güteklasse: In vivo Grade

Klon: RMP1-14-1-G6-23

Produktdetails

Expressionssystem: Mammalian cells

Verwendungszweck: In Vivo Grade Recombinant Anti-mouse PD-1 / VEGF-A Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / G6-23)

Produktmerkmale: The rat anti-mouse PD-1 monoclonal antibody (clone No. RMP1-14, rat IgG2a kappa) reacts with the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The RMP1-14 antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein. It is under investigation how the recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies (RMP1-14.1 / G6-23) behave different from the individual monoclonal antibodies and their combination. Our recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14) and the mouse anti-mouse VEGF-A antibody (hybridoma clone name or number: G6-23).

Aufreinigung: Protein A or G affinity column

Reinheit: >95 % by reducing SDS-PAGE

Endotoxin-Niveau: < 1 EU per 1 mg of the protein by the LAL method

Isotyp: IgG2c, L234A, L235A, P329G, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: > 3 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Antigendetails

Target: PD-1 & VEGF-A

Sub Type: Bispecific