Rekombinanter ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper

Produktnummer ABIN7795083

Der Humanized Monoklonal Anti-ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper wurde für FACS und in vivo validiert. Er ist geeignet, ErbB2/Her2 (Trastuzumab Biosimilar) in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper (ABIN7795083)

Target: ErbB2/Her2 (Trastuzumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Humanized

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), In vivo Studies (in vivo)

Güteklasse: Research Grade

Produktdetails anti-ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper

Expressionssystem: Mammalian cells

Verwendungszweck: Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

Produktmerkmale: Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate. There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1, HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions, when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.

Aufreinigung: Protein A or G affinity column

Reinheit: >95 % by reducing SDS-PAGE

Endotoxin-Niveau: < 1 EU per 1 mg of the protein by the LAL method

Immunogen: A431 cells overexpressing human EGFR

Isotyp: L234A, L235A, P329G

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: > 3 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Details zu ErbB2/Her2 (Trastuzumab Biosimilar)

Target: ErbB2/Her2 (Trastuzumab Biosimilar)

Andere Bezeichnung: Trastuzumab Biosimilar

Substanzklasse: Biosimilar