Der Maus Monoklonal anti-Belatacept Biosimilar Antikörper (ABIN7795081) detektiert spezifisch Belatacept Biosimilar in FACS und in vivo.
Dieser Antikörper reagiert spezifisch mit Proben aus Human.
Kurzübersicht für Rekombinanter Belatacept Biosimilar Antikörper (ABIN7795081)
Target
Belatacept Biosimilar
Antikörpertyp
Recombinant Antibody
Reaktivität
Human
Wirt
Maus
Klonalität
Monoklonal
Applikation
Flow Cytometry (FACS), In vivo Studies (in vivo)
Güteklasse
Research Grade
Expressionssystem
Mammalian cells
Verwendungszweck
Belatacept Biosimilar
Produktmerkmale
Belatacept (trade name Nulojix, Bristol-Myers-Squibb), a fusion protein of a Fc fragment (human IgG1 isotype) and the extracellular domain of CTLA-4, can be used to extend graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors. Belatacept differs from abatacept (trade name Orencia) by only 2 amino acids. The CTLA-4 protein is important for T-cell costimulation and selectively blocks the process of T-cell activation.
Aufreinigung
Protein A or G affinity column
Reinheit
>95 % by reducing SDS-PAGE
Endotoxin-Niveau
< 1 EU per 1 mg of the protein by the LAL method
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
> 3 mg/mL
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.