SARS-CoV-2 Nucleocapsid Antikörper (Biotin)

Produktnummer ABIN7794976

Dieser Anti-SARS-CoV-2 Nucleocapsid Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von SARS-CoV-2 Nucleocapsid in . Geeignet für SARS Coronavirus-2 (SARS-CoV-2).

Kurzübersicht für SARS-CoV-2 Nucleocapsid Antikörper (Biotin) (ABIN7794976)

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SARS-CoV-2 Nucleocapsid Antikörper ist konjugiert mit Biotin

Applikation: Bitte anfragen

Klon: NP1-E6

Produktdetails anti-SARS-CoV-2 Nucleocapsid Antikörper (Biotin)

Verwendungszweck: Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-E6) Biotin

Spezifität: Anti-SARS-CoV-2 Nucleocapsid, clone NP1-E6, specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Furthermore, it is reported to not bind directly to the RNA binding domain or the oligomerization domain of the N protein. Antigen Distribution The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded, positive-sense RNA virus belonging to the Coronaviridae family1. The SARS-CoV-2 genome encodes four essential proteins the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins2. SARS-CoV-2 shares 79.6 % identity with the original SARS-CoV2. The N protein is 46 kDa and consists of two highly conserved structural domains, the N-terminal domain (NTD) and C-terminal domain (CTD), connected by a linker region. The NTD and CTD are involved in a couple of primary functions, including RNA binding and self-oligomerization3,4. This results in binding to and packaging of the viral RNA genome into a helical ribonucleoprotein5. The N protein is involved in other critical steps of the viral life cycle, including transcription, replication, and modulating infected cell signaling pathways6,7. The N protein is a suitable candidate for vaccine development and diagnostic assays8 for several reasons. It is abundantly expressed during infection and is highly conserved, sharing 90 % amino acid homology with the SARS-CoV N protein9. Furthermore, antibodies9,10 and memory T cells11,12 targeting the N protein are identified in the sera of convalescent COVID-19 patients, demonstrating it as immunogenic. The N protein also suppresses antiviral RNAi, evading the innate immune system13, suggesting its potential value as a targeted therapeutic.

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/mL

Buffer: This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1 % BSA and 0.09 % sodium azide as a preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.

Details zu SARS-CoV-2 Nucleocapsid

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Andere Bezeichnung: SARS-CoV-2 Nucleocapsid (N)

Substanzklasse: Viral Protein

Hintergrund: COV2-NP1-E6, SARS-CoV-2 Nucleocapsid, SARS-CoV-2 Nucleoprotein, Protein N, SARS-CoV N Protein,