Anthrax Protective Antigen Antikörper (Internal Region)

Produktnummer ABIN7794901

Dieser Anti-Anthrax Protective Antigen Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Anthrax Protective Antigen in . Geeignet für Bacillus anthracis.

Kurzübersicht für Anthrax Protective Antigen Antikörper (Internal Region) (ABIN7794901)

Target: Anthrax Protective Antigen (PA)

Reaktivität: Bacillus anthracis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Anthrax Protective Antigen Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktdetails anti-Anthrax Protective Antigen Antikörper

Bindungsspezifität: Internal Region

Verwendungszweck: Anti-Anthrax Protective Antigen (Intermediate Domain)

Spezifität: Rabbit Anti-Anthrax Protective Antigen (Anthrax PA) recognizes an epitope in the intermediate domain of Anthrax PA. This polyclonal antibody was purified using affinity chromatography. Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin protective antigen (PA), lethal factor (LF), and edema factor (EF)1,2. PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2),4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/mL

Buffer: This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02 % sodium azide as a preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Details zu Anthrax Protective Antigen

Target: Anthrax Protective Antigen (PA)

Andere Bezeichnung: Anthrax Protective Antigen

Hintergrund: Anthrax Protective Antigen,