Anthrax Toxin Lethal Factor Antikörper (Internal Region)

Produktnummer ABIN7794899

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Anthrax Toxin Lethal Factor in . Er zeigt eine Reaktivität gegenüber Bacillus anthracis.

Kurzübersicht für Anthrax Toxin Lethal Factor Antikörper (Internal Region) (ABIN7794899)

Target: Anthrax Toxin Lethal Factor (Lef)

Reaktivität: Bacillus anthracis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Anthrax Toxin Lethal Factor Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktdetails anti-Anthrax Toxin Lethal Factor Antikörper

Bindungsspezifität: Internal Region

Verwendungszweck: Anti-Anthrax Lethal Factor (Intermediate Domain)

Spezifität: Rabbit Anti-Anthrax Lethal Factor (Anthrax LF) recognizes an epitope in the intermediate domain of Anthrax LF. This polyclonal antibody was purified using affinity chromatography. Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin protective antigen (PA), lethal factor (LF), and edema factor (EF)1,2. PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2),4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/mL

Buffer: This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02 % sodium azide as a preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Details zu Anthrax Toxin Lethal Factor

Target: Anthrax Toxin Lethal Factor (Lef)

Andere Bezeichnung: Anthrax Lethal Factor

Hintergrund: Anthrax Lethal Factor,