Haptoglobin Antikörper (AA 251-350)

Produktnummer ABIN734738

Der Kaninchen Polyklonal Anti-Haptoglobin-Antikörper wurde für WB, ELISA, IHC (p), IF (p), IF (cc) und IHC (fro) validiert. Er ist geeignet, Haptoglobin in Proben von Human, Ratte und Maus zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Haptoglobin Antikörper (AA 251-350) (ABIN734738)

Target: Haptoglobin (HP)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Haptoglobin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Haptoglobin Antikörper

Bindungsspezifität: AA 251-350

Spezifität: This protein may interact with Peptidase S1 Domain in LPA.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Hpt

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Haptoglobin Antikörper (ABIN734738)

Kälsch, Pott, Takeda, Kumamoto, Möllmann, Canbay, Sitek, Baba: "Bathing in carbon dioxide-enriched water alters protein expression in keratinocytes of skin tissue in rats." in: International journal of biometeorology, (2016) (PubMed).

Details zu Haptoglobin

Target: Haptoglobin (HP)

Hintergrund:

Synonyms: BP, HPA1S, HP2ALPHA2, Haptoglobin, Zonulin, HP

Background: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Gen-ID: 3240

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis