FOXP3 Antikörper (FineTest®700)

Produktnummer ABIN7675503

Dieses Maus Monoklonal-Antikörper erkennt spezifisch FOXP3 in FACS. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für FOXP3 Antikörper (FineTest®700) (ABIN7675503)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist konjugiert mit FineTest®700

Applikation: Flow Cytometry (FACS)

Klon: 3G3

Produktdetails anti-FOXP3 Antikörper (FineTest®700)

Verwendungszweck: FineTest®700 Anti-Mouse Foxp3 Antibody

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 %BSA, pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: Foxp3

Hintergrund:

Synonyms: Forkhead box protein P3|Foxp3|IPEX|JM2

Background: Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence, the other (Foxp3 δ2) lacking exon 2.

Molekulargewicht: 0

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation