CCR6 Antikörper (FineTest®700)

Produktnummer ABIN7675403

Dieses Anti-CCR6-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CCR6 in FACS. Geeignet für Human.

Kurzübersicht für CCR6 Antikörper (FineTest®700) (ABIN7675403)

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCR6 Antikörper ist konjugiert mit FineTest®700

Applikation: Flow Cytometry (FACS)

Klon: G034E3

Produktdetails anti-CCR6 Antikörper (FineTest®700)

Verwendungszweck: FineTest®700 Anti-Human CD196/CCR6 Antibody

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 %BSA, pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu CCR6

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Andere Bezeichnung: CD196

Hintergrund:

Synonyms: CMKBR6|GPR29|STRL22|CKRL3|GPRCY4|CCR6

Background: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Molekulargewicht: 0

Gen-ID: 1235

UniProt: P51684

Pathways: cAMP Metabolic Process