Haptoglobin Antikörper (AA 180-406)

Produktnummer ABIN7673380

Dieses Anti-Haptoglobin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Haptoglobin in WB und ELISA. Geeignet für Human und Schwein.

Kurzübersicht für Haptoglobin Antikörper (AA 180-406) (ABIN7673380)

Target: Haptoglobin (HP)

Reaktivität: Human, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Haptoglobin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 7C8

Produktdetails anti-Haptoglobin Antikörper

Bindungsspezifität: AA 180-406

Verwendungszweck: HP antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 180-406aa

Immunogen: haptoglobin

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:2000 - 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu Haptoglobin

Target: Haptoglobin (HP)

Andere Bezeichnung: HP

Hintergrund:

Synonyms: Haptoglobin|Zonulin|Haptoglobin alpha chain|Haptoglobin beta chain|HP

Background: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Molekulargewicht: 42 kDa

Gen-ID: 3240

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis