8-OHDG Antikörper

Produktnummer ABIN7672607

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch 8-OHDG in IHC und IF. Er zeigt eine Reaktivität gegenüber .

Kurzübersicht für 8-OHDG Antikörper (ABIN7672607)

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 8-OHDG Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-8-OHDG Antikörper

Verwendungszweck: 8-OHDG antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: KLH conjugated 8-OHdG

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC: 1:50 - 1:500, IF: 1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.06 % PC300 and 50 % glycerol pH 7.3,

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu 8-OHDG

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Andere Bezeichnung: 8-OHDG

Substanzklasse: Chemical

Hintergrund:

Synonyms: 8-hydroxy-2'-deoxyguanosine|2'-Deoxy-8-oxoguanosine|7,8-Dihydro-8-oxo-2'-deoxyguanosine|8-Oxo-7,8-dihydro-2'-deoxyguanosine|8-Oxo-7,8-dihydrodeoxyguanosine|2'-Deoxy-8-oxo-D-guanosine|8-Oxo-7,8-dihydro-2μ-deoxyguanosine,8-Oxo-dG|2'-Deoxy-8-hydroxyguanosine

Background: 8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.