Osteocalcin Antikörper

Produktnummer ABIN7670704

Dieses Anti-Osteocalcin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Osteocalcin in ELISA (Detection). Geeignet für Ratte.

Kurzübersicht für Osteocalcin Antikörper (ABIN7670704)

Target: Osteocalcin (BGLAP)

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Osteocalcin Antikörper ist unkonjugiert

Applikation: ELISA (Detection)

Klon: 7G10

Produktdetails anti-Osteocalcin Antikörper

Verwendungszweck: Osteocalcin Monoclonal Antibody(Detector)

Aufreinigung: Protein A/G Purification

Immunogen: Recombinant Rat Osteocalcin protein expressed by E.coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu Osteocalcin

Target: Osteocalcin (BGLAP)

Andere Bezeichnung: Osteocalcin

Hintergrund: OsteocaLcin,Bone GLa protein (BGP),Gamma-carboxygLutamic acid-containing protein,BgLap,BgLap2,The carboxylated form is one of the main organic components of the bone matrix,which constitutes 1-2 % of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium. The uncarboxylated form acts as a hormone secreted by osteoblasts,which regulates different cellular processes,such as energy metabolism,male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation,insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of leydig cells,initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons,initiating a signaling response that prevents neuronal apoptosis in the hippocampus,favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.

UniProt: P04640