Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C Valid for 1 month or -20°C Valid for 12 months
Haltbarkeit
12 months
Target
FETUB
(Fetuin B (FETUB))
Andere Bezeichnung
Fetuin B
Hintergrund
2310011O17Rik,AI255764,D17980,Gugu,Fetub,Fetuins are members of the cystatin superfamily of cysteine protease inhibitors. Additional members of this superfamily are kininogen and histidine-rich glycoprotein. Fetuin A and B are two known members of the fetuin family. Hepatocytes are believed to be the principal cellular source, but other cell types also express it. Fetuin A, also known as alpha 2-Heremans-Schmid glycoprotein, is an inhibitor of basic calcium phosphate precipitation and a negative acute-phase protein. Normal circulating levels of Fetuin A in adults (300?600 μg/mL) fall significantly (30?50 % ) during injury and infection. Fetuin B is a newer member whose function is not fully characterized. Fetuin A and B display similarities and differences in their characteristics. Fetuin B exhibits reduction of calcification, while both mRNA levels were down?regulated during the acute phase in inflammation-induced rats. However, they share only 20 % amino acid sequence identity. The amounts of Fetuin B in human serum, unlike Fetuin A, vary with gender and are higher in females than in males.