Cortisol Binding Globulin Antikörper

Produktnummer ABIN7670581

Dieses Anti-Cortisol Binding Globulin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cortisol Binding Globulin in WB, ELISA und IF. Geeignet für Human und Maus.

Kurzübersicht für Cortisol Binding Globulin Antikörper (ABIN7670581)

Target: Cortisol Binding Globulin

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cortisol Binding Globulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-Cortisol Binding Globulin Antikörper

Verwendungszweck: Cortisol Binding Globulin/CBG/SERPINA6 Polyclonal Antibody(Capture/Detector)

Aufreinigung: Antigen Affinity Purification

Immunogen: Recombinant Human Cortisol Binding Globulin/CBG/SERPINA6 SERPINA6 Protein expressed by Mammalian

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000,IF 1:50-1:200,ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu Cortisol Binding Globulin

Target: Cortisol Binding Globulin

Hintergrund: Corticosteroid-binding gLobuLin,CBG,Serpin A6,Transcortin,SERPINA6,CBG,Corticosteroid-binding globulin (CBG),also known as SerpinA6,is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG,and promotes a significant and local release of glucocorticoids (over 90 % of them are bound to CBG in human plasma). In this context,CBG directs glucocorticoids to sites of inflammation,and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration,and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable,human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.

Molekulargewicht:

Calculated MW: 45kDa

ObservedMW: 60kDa

UniProt: P08185