Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C Valid for 1 month or -20°C Valid for 12 months
Haltbarkeit
12 months
Target
Coagulation Factor IX (F9)
Andere Bezeichnung
F9
Hintergrund
HEMB,P19,PTC,THPH8,Christmas Factor,This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.