MCAM Antikörper (PE)

Produktnummer ABIN7670248

Der Ratte Monoklonal Anti-MCAM-Antikörper wurde für FACS validiert. Er ist geeignet, MCAM in Proben von Maus zu detektieren.

Kurzübersicht für MCAM Antikörper (PE) (ABIN7670248)

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser MCAM Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: ME-9F1

Produktdetails anti-MCAM Antikörper (PE)

Verwendungszweck: PE Anti-Mouse CD146 Antibody[ME-9F1]

Immunogen: E-AB-F09832D

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 5 μL/tests

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant

Handhabung: Please protected from prolonged exposure to light and do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: This product can be stored at 2-8°C for 12 months.

Haltbarkeit: 12 months

Details zu MCAM

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Andere Bezeichnung: CD146

Hintergrund: S-Endo 1 antigen,MUC18,MCAM,Mel-CAM,A32 antigen,CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, S-Endo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig superfamily. CD146 is strongly expressed by murine vascular endothelial cells. It is expressed on about 30 % of neutrophils and 60 % of NK cells. Unlike in humans, CD146 is undetectable on monocytes, dendritic cells, T cells, NKT cells, B cells, or smooth muscle cells in mouse. It has been reported that an increase in CD146 expression is associated with NK cell maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative marker to detect final stages of NK cell maturation and define NK cell subsets. CD146+ NK cells were found to be less cytotoxic and to produce less IFNγ than CD146- NK cells upon stimulation with target cells or activating antibodies. The role of CD146 on NK cell migration has yet to be investigated. The identification of CD146 ligand(s) will be crucial to address this issue.

UniProt: P10810