CCR2 Antikörper

Produktnummer ABIN7670040

Dieser Maus Monoklonal Antikörper detektiert spezifisch CCR2 in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CCR2 Antikörper (ABIN7670040)

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCR2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: K036C2

Produktdetails anti-CCR2 Antikörper

Verwendungszweck: Purified Anti-Human CD192 Antibody[K036C2]

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze / thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu CCR2

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Andere Bezeichnung: CD192

Hintergrund: CKR,CMKBR,CC-CKR,CCR,CCR2,CC-CKR-2,CCR-2,CCR2A,CCR2B,CD192,CKR2,CKR2A,CKR2B,CMKBR2,MCP-1-R,FLJ78302,C C chemokine receptor type 2,C C CKR 2,CC chemokine receptor type 2,C-C chemokine receptor type 2,CC CKR 2,C-C CKR-2,CCCKR2,CCR 2,CCR1L,CCR5L,CD192 antigen,Chemokine C C motif receptor 2,Chemokine CC Motif Receptor 2,CKR 2,cluster of differentiation 192,MCP 1 R,MCP1 RECEPTOR,MCP1R,MCP-1-R,Monocyte chemoattractant protein 1 receptor,Monocyte Chemotactic Protein 1 Receptor,CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.

UniProt: P41597

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process