OxLDL Antikörper

Produktnummer ABIN733148

Der Kaninchen Polyklonal Anti-OxLDL-Antikörper wurde für IF (p), FACS, IF (cc), IHC (p), ELISA und IHC (fro) validiert. Er ist geeignet, OxLDL in Proben von Maus und Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für OxLDL Antikörper (ABIN733148)

Target: OxLDL (Oxidized Low Density Lipoprotein (OxLDL))

Reaktivität: Maus, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OxLDL Antikörper ist unkonjugiert

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-OxLDL Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified by Protein A.

Immunogen: Full length plasma protein (Human)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-OxLDL Antikörper (ABIN733148)

Wang, Li, Zhen, Xu, Sun: "Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy." in: International journal of clinical and experimental pathology, Vol. 8, Issue 12, pp. 15696-707, (2016) (PubMed).

Martinez, Malireddi, Lu, Cunha, Pelletier, Gingras, Orchard, Guan, Tan, Peng, Kanneganti, Virgin, Green: "Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins." in: Nature cell biology, Vol. 17, Issue 7, pp. 893-906, (2015) (PubMed).

Wen, Liu, Liu, Harris, Yao, Ding, Nie, Lu, Chen, An, Zang, Teng: "OxLDL-targeted iron oxide nanoparticles for in vivo MRI detection of perivascular carotid collar induced atherosclerotic lesions in ApoE-deficient mice." in: Journal of lipid research, Vol. 53, Issue 5, pp. 829-38, (2012) (PubMed).

Details zu OxLDL

Target: OxLDL (Oxidized Low Density Lipoprotein (OxLDL))

Andere Bezeichnung: ox-LDL

Hintergrund:

Synonyms: ox-LDL: Cu2SO4 oxidized low density lipoprotein, oxidized low density lipoprotein, Low density lipoprotein, MDA oxidized LDL, MDA oxidized low density lipoprotein.

Background: Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. Low-density lipoprotein oxidised with Cu2SO4.