ZFYVE28 Antikörper (CF®640R)

Produktnummer ABIN7662127

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ZFYVE28 in IHC und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ZFYVE28 Antikörper (CF®640R) (ABIN7662127)

Target: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ZFYVE28 Antikörper ist konjugiert mit CF®640R

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: LST2-2426

Produktdetails anti-ZFYVE28 Antikörper (CF®640R)

Verwendungszweck: ZFYVE28 (Zinc Finger FYVE-type containing 28)(LST2/2426), CF640R conjugate

Produktmerkmale: ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human ZFYVE28 protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: PC3 cells. Testis, Brain, Colon, Kidney or Stomach.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu ZFYVE28

Target: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Andere Bezeichnung: ZFYVE28

Hintergrund:

Synonyms: Lateral signaling target protein 2 homolog, LST2, LYST2, Zinc finger FYVE domain-containing protein 28 (ZFYVE28)

Gene Symbol: ZFYVE28

Molekulargewicht: 96 kDa

Gen-ID: 57732

Pathways: EGFR Signaling Pathway