Transferrin Antikörper (AA 311-445) (CF®488A)

Produktnummer ABIN7661009

Der Maus Monoklonal Anti-Transferrin-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, Transferrin in Proben von Human zu detektieren.

Kurzübersicht für Transferrin Antikörper (AA 311-445) (CF®488A) (ABIN7661009)

Target: Transferrin (TF)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Antikörper ist konjugiert mit CF®488A

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: TF-3001

Produktdetails anti-Transferrin Antikörper (CF®488A)

Bindungsspezifität: AA 311-445

Verwendungszweck: Transferrin (Early Marker of Oligodendrocytes)(TF/3001), CF488A conjugate

Produktmerkmale: Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 311-445) of human TF protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: Jurkat, HeLa, MCF-7 or K562 cells. Human liver.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Transferrin

Target: Transferrin (TF)

Andere Bezeichnung: Transferrin

Hintergrund:

Synonyms: Apotransferrin, Beta-1 metal-binding globulin, Serotransferrin, Siderophilin, TF, TFQTL1, Transferrin

Gene Symbol: TF

Molekulargewicht: 79 kDa

Gen-ID: 7018

UniProt: P02787

Pathways: Transition Metal Ion Homeostasis