STAR Antikörper (AA 39-108) (CF®488A)

Produktnummer ABIN7660409

Der Maus Monoklonal Anti-STAR-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, STAR in Proben von Human zu detektieren.

Kurzübersicht für STAR Antikörper (AA 39-108) (CF®488A) (ABIN7660409)

Target: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STAR Antikörper ist konjugiert mit CF®488A

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: STAR-2077

Produktdetails anti-STAR Antikörper (CF®488A)

Bindungsspezifität: AA 39-108

Verwendungszweck: StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker)(STAR/2077), CF488A conjugate

Produktmerkmale: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 39-108) of human STAR protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: K-562 cells. Adrenal or Testicular Carcinoma

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu STAR

Target: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Andere Bezeichnung: StAR

Hintergrund:

Synonyms: Cholesterol trafficker, Luteinizing hormone induced protein, Mitochondrial steroid acute regulatory protein, StAR, StAR related lipid transfer (START) domain containing 1, StARD1, START domain-containing protein 1, Steroid acute regulatory protein, Steroidogenic acute regulator (STAR), Steroidogenic acute regulatory protein mitochondrial

Gene Symbol: STAR

Tissue Expression: Adrenal gland|Ovary|Testis

Molekulargewicht: ~30 kDa

Gen-ID: 6770

UniProt: P49675

Pathways: Metabolism of Steroid Hormones and Vitamin D, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis