KRT14 Antikörper (AA 351-472) (CF®488A)

Produktnummer ABIN7655923

Dieses Maus Monoklonal-Antikörper erkennt spezifisch KRT14 in IHC, FACS und IHC (fp). Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus und Schwein.

Kurzübersicht für KRT14 Antikörper (AA 351-472) (CF®488A) (ABIN7655923)

Target: KRT14 (Keratin 14 (KRT14))

Reaktivität: Human, Ratte, Maus, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KRT14 Antikörper ist konjugiert mit CF®488A

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: KRT14-2375

Produktdetails anti-KRT14 Antikörper (CF®488A)

Bindungsspezifität: AA 351-472

Verwendungszweck: Cytokeratin 14 (KRT14) (Squamous Cell Marker)(KRT14/2375), CF488A conjugate

Produktmerkmale: Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human KRT14 fragment (around aa351-472)

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: A431 or HeLa cells. Skin or Squamous Cell Carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu KRT14

Target: KRT14 (Keratin 14 (KRT14))

Andere Bezeichnung: Keratin 14

Hintergrund:

Synonyms: CK-14, Dowling Meara, ebs3, ebs4, Epidermolysis Bullosa Simplex, k14, Keratin 14, Keratin Type I Cytoskeletal 14, Koebner, krt14, NFJ

Gene Symbol: KRT14

Tissue Expression: Epithelial cells

Molekulargewicht: ~50 kDa

Gen-ID: 3861

UniProt: P02533