Rekombinanter Filaggrin Antikörper (AA 198-288) (CF®640R)

Produktnummer ABIN7654074

Dieses Anti-Filaggrin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Filaggrin in IHC und IHC (fp). Geeignet für Human.

Kurzübersicht für Rekombinanter Filaggrin Antikörper (AA 198-288) (CF®640R) (ABIN7654074)

Target: Filaggrin (FLG)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Filaggrin Antikörper ist konjugiert mit CF®640R

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: RFLG-1561

Produktdetails anti-Filaggrin Antikörper (CF®640R)

Bindungsspezifität: AA 198-288

Verwendungszweck: Filaggrin (Keratinocyte Differentiation Marker)(rFLG/1561), CF640R conjugate

Produktmerkmale: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human Filaggrin protein fragment (aa 198-288)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: U-251-MG cells. Skin.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Filaggrin

Target: Filaggrin (FLG)

Andere Bezeichnung: Filaggrin

Hintergrund:

Synonyms: ATOD2, Epidermal Filaggrin, Filaggrin, Filaggrin precursor, Fillagrin, FLG, Profilaggrin

Gene Symbol: FLG

Molekulargewicht: 26-45 kDa (Processed), 350 kDa (Profilaggrin)

Gen-ID: 2312

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance