Desmoglein 3 Antikörper (AA 379-491) (CF®640R)

Produktnummer ABIN7653125

Der Maus Monoklonal Anti-Desmoglein 3-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, Desmoglein 3 in Proben von Human zu detektieren.

Kurzübersicht für Desmoglein 3 Antikörper (AA 379-491) (CF®640R) (ABIN7653125)

Target: Desmoglein 3 (DSG3)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmoglein 3 Antikörper ist konjugiert mit CF®640R

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: DSG3-2838

Produktdetails anti-Desmoglein 3 Antikörper (CF®640R)

Bindungsspezifität: AA 379-491

Verwendungszweck: Desmoglein-3 (Squamous Cell Marker)(DSG3/2838), CF640R conjugate

Produktmerkmale: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 379-491) human DSG3 protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Desmoglein 3

Target: Desmoglein 3 (DSG3)

Andere Bezeichnung: Desmoglein-3

Hintergrund:

Synonyms: 130 kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3)

Gene Symbol: DSG3

Tissue Expression: Epidermal cells

Molekulargewicht: 130 kDa

Gen-ID: 1830

UniProt: P32926