CD7 Antikörper (CF®647)

Produktnummer ABIN7651931

Der Maus Monoklonal Anti-CD7-Antikörper wurde für IF validiert. Er ist geeignet, CD7 in Proben von Human zu detektieren.

Kurzübersicht für CD7 Antikörper (CF®647) (ABIN7651931)

Target: CD7

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD7 Antikörper ist konjugiert mit CF®647

Applikation: Immunofluorescence (IF)

Klon: HuLy-m2

Produktdetails anti-CD7 Antikörper (CF®647)

Verwendungszweck: CD7 (T-Cell Leukemia Marker)(HuLy-m2), CF647 conjugate

Produktmerkmale: Recognizes a protein of 40 kDa, identified as CD7 (Workshop IV, Code T165). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Immunogen: Human thymocytes

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Flow cytometry: 0.5-1 μg/million cells. Immunofluorescence: 0.5-1 μg/mL. Optimal dilution for a specific application should be determined by user

Kommentare:

Positive Control: Jurkat, HUT-78, Molt-4, CEM cells, or human peripheral blood lymphocytes. Lymph node and tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu CD7

Target: CD7

Andere Bezeichnung: CD7

Hintergrund:

Synonyms: GP40, Leu9, p41, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41

Gene Symbol: CD7

Tissue Expression: NK cells|T-cells

Molekulargewicht: 40 kDa

Gen-ID: 924

UniProt: P09564

Pathways: Cell-Cell Junction Organization