Rekombinanter CD207 Antikörper (AA 74-213) (CF®740)

Produktnummer ABIN7650961

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch CD207 in . Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter CD207 Antikörper (AA 74-213) (CF®740) (ABIN7650961)

Target: CD207 (CD207 Molecule, Langerin (CD207))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CD207 Antikörper ist konjugiert mit CF®740

Applikation: Bitte anfragen

Klon: LGRN-3136R

Produktdetails anti-CD207 Antikörper (CF®740)

Bindungsspezifität: AA 74-213

Verwendungszweck: Langerin / CD207 (Marker of Langerhans Cells)(LGRN/3136R), CF740 conjugate

Produktmerkmale: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2 -dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa74-213) of human Langerin protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Kommentare:

Positive Control: HeLa or A549 cells. Skin.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Andere Bezeichnung: CD207

Hintergrund:

Synonyms: C-type lectin domain family 4 member K, CD207, CLEC4K, Langerhans cell specific c type lectin, Langerin

Gene Symbol: CD207

Tissue Expression: Heart|Lymph node|Dendritic cells|Liver|Lung|Spleen|Thymus

Molekulargewicht: 48 kDa

Gen-ID: 50489

UniProt: Q9UJ71