Annexin a1 Antikörper (CF®647)

Produktnummer ABIN7649520

Dieses Anti-Annexin a1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Annexin a1 in WB, IHC, FACS und IHC (fp). Geeignet für Human.

Kurzübersicht für Annexin a1 Antikörper (CF®647) (ABIN7649520)

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Annexin a1 Antikörper ist konjugiert mit CF®647

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: ANXA1-1671

Produktdetails anti-Annexin a1 Antikörper (CF®647)

Verwendungszweck: Annexin A1 / (Hairy Cell Leukemia Marker)(ANXA1/1671), CF647 conjugate

Produktmerkmale: Annexin A1 belongs to the annexin family. It plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. In resting conditions Annexin A1 is localized to the cytoplasm. Upon activation it is mobilized to the membrane and secreted. Annexin A1 and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. Expression of the ANXA1 gene is upregulated in hairy cell leukemia (HCL). Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human Annexin A1 protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: A431 and K562 cell lysates. Human esophagus, placenta and prostate tissues.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Annexin a1

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Andere Bezeichnung: Annexin A1

Hintergrund:

Synonyms: Annexin-1, Calpactin-2, Chromobindin-9, Phospholipase A2 inhibitory protein, LPC1, p35

Gene Symbol: ANXA1

Molekulargewicht: 35 kDa

Gen-ID: 301

UniProt: P04083

Pathways: Hormone Transport