AKR1B1 Antikörper (CF®594)

Produktnummer ABIN7649347

Dieses Maus Monoklonal-Antikörper erkennt spezifisch AKR1B1 in WB, IHC, IF und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für AKR1B1 Antikörper (CF®594) (ABIN7649347)

Target: AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AKR1B1 Antikörper ist konjugiert mit CF®594

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: CPTC-AKR1B1-2

Produktdetails anti-AKR1B1 Antikörper (CF®594)

Verwendungszweck: Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)(CPTC-AKR1B1-2), CF594 conjugate

Produktmerkmale: Aldo-keto Reductase Family 1 Member B1 (AKR1B1), also known as aldose reductase or aldehyde reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human AKR1B1 protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: 549, 293T, A431, HeLa, HepG2, MOLT4 and Raji whole cell lysates, HeLa cells, Human colon carcinoma tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu AKR1B1

Target: AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))

Andere Bezeichnung: Aldo-keto Reductase Family 1 Member B1

Hintergrund:

Synonyms: Aldo-keto reductase family 1 member B1, AKR1B1, Aldehyde Reductase 1, Aldose reductase, Lii5-2 CTCL tumor antigen, low Km aldose reductase

Gene Symbol: AKR1B1

Molekulargewicht: 37 kDa

Gen-ID: 231

UniProt: P15121

Pathways: Metabolism of Steroid Hormones and Vitamin D, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process