TRIM32 Antikörper (AA 301-400) (Biotin)

Produktnummer ABIN730335

Dieses Anti-TRIM32-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TRIM32 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Maus.

Kurzübersicht für TRIM32 Antikörper (AA 301-400) (Biotin) (ABIN730335)

Target: TRIM32 (Tripartite Motif Containing 32 (TRIM32))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM32 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-TRIM32 Antikörper (Biotin)

Bindungsspezifität: AA 301-400

Kreuzreaktivität: Maus

Homologie: Human,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse TRIM32

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu TRIM32

Target: TRIM32 (Tripartite Motif Containing 32 (TRIM32))

Andere Bezeichnung: TRIM32/BBS11

Hintergrund:

Synonyms: 72 kda Tat interacting Protein, BBS11, HT2A, LGMD2H, Limb girdle muscular dystrophy 2H autosomal recessive, Limb girdle muscular dystrophy 2H, Muscular dystrophy Hutterite type, TAT interactive protein 72KD, TATIP, Tripartite Mot Containing Protein 32, Zinc Finger Protein HT2A, TRI32_MOUSE.

Background: Tripartite motif-containing protein 32 (TRIM32) belongs to the tripartite motif (TRIM) protein family. TRIM32, like all TRIM proteins, contains a domain structure composed of a B-box, a RING-finger and a coiled-coil motif. Additionally, TRIM32 has six C-terminal NHL domains, it is expressed mainly in the skeletal muscle. The TRIM32 gene encodes an E3 ubiquitin ligase, a protein that attaches ubiquitin to a lysine residue on a target protein and acts in conjunction with ubiquitin-conjugating enzymes UbcH5a, UbcH5c and UbcH6. Mutations in the TRIM32 gene cause two forms of autosomal recessive muscular dystrophy designated limb girdle muscular dystrophy type 2H (LGMD2H) and sarcotubular myopathy (STM). TRIM32 mutations can also result in Bardet-Biedl syndrome (BBS), an autosomal recessive disorder characterized by pigmentary retinopathy, polydactyly, hypogenitalism, renal abnormalities, learning disabilities and obesity.

Gen-ID: 22954

Pathways: Negative Regulation of intrinsic apoptotic Signaling