PAR1 Antikörper (AA 251-350)

Produktnummer ABIN728743

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch PAR1 in WB, ELISA, IHC (p), IF (cc), IF (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für PAR1 Antikörper (AA 251-350) (ABIN728743)

Target: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PAR1 Antikörper

Bindungsspezifität: AA 251-350

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PAR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-PAR1 Antikörper (ABIN728743)

Posthuma, Posma, Schep, Bender, van Oerle, van der Wal, Ten Cate, Spronk: "Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes." in: Journal of vascular surgery, Vol. 69, Issue 4, pp. 1243-1250, (2019) (PubMed).

Ben Shimon, Zeimer, Shavit Stein, Artan-Furman, Harnof, Chapman, Eisenkraft, Pick, Maggio: "Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus." in: PLoS ONE, Vol. 12, Issue 11, pp. e0188524, (2017) (PubMed).

Fan, Chen, Ni, Wang, Sun, Chen, Zheng: "Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers." in: OncoTargets and therapy, Vol. 8, pp. 1619-26, (2015) (PubMed).

Acton, Miles: "Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine." in: PLoS ONE, Vol. 10, Issue 8, pp. e0134488, (2015) (PubMed).

Liu, Xie, Luo, Chen, Zhou, Xia, Chen, Zhou, Cao, Cao, Zhou: "Identification of FLOT2 as a novel target for microRNA-34a in melanoma." in: Journal of cancer research and clinical oncology, (2014) (PubMed).

Details zu PAR1

Target: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Andere Bezeichnung: Thrombin receptor

Hintergrund:

Synonyms: TR, HTR, CF2R, PAR1, PAR-1, Proteinase-activated receptor 1, Coagulation factor II receptor, Thrombin receptor, F2R

Background: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Gen-ID: 2149

UniProt: P25116

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus